The major focus of my research program is to improve the diagnosis and treatment of patients with tuberculosis (TB). Each year, nearly 2 million of the 8 million estimated patients with TB worldwide are “missed”. The failure to diagnose TB rapidly and initiate treatment contributes to worse outcomes for patients and ongoing transmission of the disease in the community. To address this challenge, I have developed an innovative research program that spans the translational research spectrum. First, my group collaborates actively with basic scientists and engineers to identify novel biomarkers for TB screening and diagnosis and to develop point-of-care platforms for biomarker detection. Second, we conduct primary studies at field sites in Uganda and the Philippines and systematic reviews to support guideline development for TB diagnostics. We focus not only on diagnostic accuracy but also on evaluating the impact of new diagnostics on clinical decisions and patient outcomes. Third, we measure the quality of care delivered to patients with TB and use implementation science-based approaches to develop and test strategies to improve care delivery. Our expertise in this area has led to collaborations to study and improve care delivery for other lung health conditions (e.g., asthma, COPD) in domestic and international settings.